Targeted induction of endogenous NKX3‐1 by small activating RNA inhibits prostate tumor growth
Abstract
RNA activation (RNAa) is a small RNA‐mediated gene regulation mechanism by which expression of a particular gene can be induced by targeting its promoter using small double‐stranded RNA also known as small activating RNA (saRNA). We used saRNA as a molecular tool to examine NKX3‐1's role as a tumor suppressor and tested in vitro and in vivo antitumor effects of NKX3‐1 induction by saRNA.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 08, 2013
- Source ID
- 10.1002/pros.22709
Entities
People
- Ji Wang
- Long‐cheng Li
- Moo Rim Kang
- Robert F. Place
- Shancheng Ren
- Vera Huang
- Yinhao Sun
Organizations
- National Institutes of Health
- National Natural Science Foundation of China
- Naval Medical University
- University of California, San Francisco