Telomere length as a risk factor for hereditary prostate cancer
Abstract
Telomeres are repetitive nucleotide sequences that stabilize the ends of chromosomes. Critically short telomeres are thought to contribute to cancer development by increasing chromosomal instability. We hypothesized that shorter leukocyte telomere length, a surrogate for inherited prostate cell telomere length, would be associated with increased risk of prostate cancer in hereditary prostate cancer (HPC) families.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 28, 2013
- Source ID
- 10.1002/pros.22755
Entities
People
- Alan K Meeker
- Angelo M De Marzo
- Christopher M Heaphy
- Corinne Joshu
- Elizabeth A Platz
- Kathy E. Wiley
- Lauren M Hurwitz
- Sally D. Isaacs
- William B Isaacs
- Yuko Konishi
Organizations
- Johns Hopkins Bloomberg School of Public Health
- Johns Hopkins School of Medicine
- Sidney Kimmel Comprehensive Cancer Center
- United States Department of Defense