Case‐only gene–environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer
Abstract
Black men have historically had higher blood lead levels than white men in the U.S. and have the highest incidence of prostate cancer in the world. Inorganic lead has been classified as a probable human carcinogen. Lead (Pb) inhibits delta‐aminolevulinic acid dehydratase (ALAD), a gene recently implicated in other genitourinary cancers. The ALAD enzyme is involved in the second step of heme biosynthesis and is an endogenous inhibitor of the 26S proteasome, a master system for protein degradation and a current target of cancer therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 05, 2014
- Source ID
- 10.1002/pros.22781
Entities
People
- Albert M Levin
- Andrew Rundle
- Benjamin A. Rybicki
- Bharati Mitra
- Cathryn H. Bock
- Christine Neslund‐dudas
- Deliang Tang
- Indrani Datta
- Jennifer Beebe‐dimmer
- Michelle Jankowski
- Nora L. Nock
- Q. Ping Dou
- Richard Krajenta
Organizations
- Case Western Reserve University
- Columbia University
- Congressionally Directed Medical Research Programs
- Henry Ford Health
- National Institute of Environmental Health Sciences
- Wayne State University