Loss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytes
Abstract
The influence of pattern recognition receptor (PRR) signaling in the prostate tumor microenvironment remains unclear. Although there may be a role for PRR agonists as adjuvants to therapy, prior evidence suggests tumor promoting as well as tumor inhibiting mechanisms. The purpose of this study is to examine the role of the key Toll‐like receptor (TLR) signaling adaptor protein myeloid differentiation primary response gene 88 (MyD88) in prostate cancer development.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 16, 2015
- Source ID
- 10.1002/pros.22932
Entities
People
- Arnold I. Chin
- Elizabeth M. Peek
- Hanwei Zhang
- Jiaoti Huang
- Wang Song
Organizations
- Jilin University
- Stop Cancer
- United States Department of Defense
- University of California, Los Angeles