Androgens regulate SMAD ubiquitination regulatory factor‐1 expression and prostate cancer cell invasion
Abstract
Prostate cancer (PCa) is the most commonly diagnosed male cancer in the United States and is a hormone‐driven disease. Androgens have been recognized as a major promoter of PCa development and progression. However, the mechanism of androgen action in PCa, especially in PCa cell invasion and metastasis remains largely unclear. SMAD ubiquitination regulatory factor‐1 (SMURF1) is a C2‐WW‐HECT‐domain E3 ubiquitin ligase that plays important roles in cancer cell metastasis. Whether there is a relationship between androgens and SMURF1 expression is not known.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 28, 2015
- Source ID
- 10.1002/pros.22935
Entities
People
- Guixia Wang
- Haojie Huang
- Xiaokun Gang
Organizations
- Jilin University
- Mayo Clinic
- Mayo Medical School
- National Institutes of Health
- National Natural Science Foundation of China
- United States Department of Defense