NUSAP1 expression is upregulated by loss of RB1 in prostate cancer cells
Abstract
Overexpression of NUSAP1 is associated with poor prognosis in prostate cancer, but little is known about what leads to its overexpression. Based on previous observations that NUSAP1 expression is enhanced by E2F1, we hypothesized that NUSAP1 expression is regulated, at least in part, by loss of RB1 via the RB1/E2F1 axis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 13, 2015
- Source ID
- 10.1002/pros.22938
Entities
People
- Catherine A. Gordon
- James D Brooks
- Zulfiqar G. Gulzar
Organizations
- Stanford University
- United States Department of Defense