Differential gene expression profiling of functionally and developmentally distinct human prostate epithelial populations
Abstract
Human fetal prostate buds appear in the 10th gestational week as solid cords, which branch and form lumens in response to androgen 1. Previous in vivo analysis of prostate epithelia isolated from benign prostatectomy specimens indicated that Epcam+CD44−CD49fHi basal cells possess efficient tubule initiation capability relative to other subpopulations 2. Stromal interactions and branching morphogenesis displayed by adult tubule‐initiating cells (TIC) are reminiscent of fetal prostate development. In the current study, we evaluated in vivo tubule initiation by human fetal prostate cells and determined expression profiles of fetal and adult epithelial subpopulations in an effort to identify pathways used by TIC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 07, 2015
- Source ID
- 10.1002/pros.22959
Entities
People
- Baohui Zhang
- Dong Sun An
- Haibo Liu
- Isla P Garraway
- Kevin Lai
- Lihong Huo
- Michael Lewis
- Radu M. Cadaneanu
- Xinmin Li
Organizations
- Jean Perkins Foundation
- National Institutes of Health
- Prostate Cancer Foundation
- UCLA David Geffen School of Medicine
- United States Department of Defense
- University of California, Los Angeles
- Veterans Health Administration