Expression of spermidine/spermine N1‐acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis
Abstract
Prostate cancer (PCa) in many patients remains indolent for the rest of their lives, but in some patients, it progresses to lethal metastatic disease. Gleason score is the current clinical method for PCa prognosis. It cannot reliably identify aggressive PCa, when GS is ≤ 7. It is shown that oxidative stress plays a key role in PCa progression. We have shown that in cultured human PCa cells, an activation of spermidine/spermine N1‐acetyl transferase (SSAT; EC 2.3.1.57) enzyme initiates a polyamine oxidation pathway and generates copious amounts of reactive oxygen species in polyamine‐rich PCa cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 20, 2015
- Source ID
- 10.1002/pros.22996
Entities
People
- Dawn R. Church
- Farideh Mehraein‐ghomi
- George Wilding
- Hirak S. Basu
- Jens C. Eickhoff
- Wei Huang
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Wisconsin–Madison