Human herpesvirus 8 establishes a latent infection in prostates of Tobago men resulting in increased macrophage infiltration

Abstract

The Caribbean island of Tobago, which is 97% African ancestry, has one of the highest rates of prostate cancer in the world. We have previously reported that human herpesvirus 8 (HHV‐8) infection is significantly associated with prostate cancer in Tobago. In this study, we extend those results testing the hypothesis that HHV‐8 seropositive Tobagonian men have a chronic HHV‐8 infection in their prostates that is associated with increased inflammation.

Document Details

Document Type
Pub Defense Publication
Publication Date
Feb 05, 2016
Source ID
10.1002/pros.23163

Entities

People

  • Alan L. Patrick
  • Clareann H. Bunker
  • Frank J. Jenkins
  • Jill D. Henning

Organizations

  • National Institutes of Health
  • University of Pittsburgh
  • University of Pittsburgh Cancer Institute

Tags

Readers

  • Infectious Disease/Epidemiology
  • International Relations, focusing on Korea-Africa and North Korea-South Korea relations, and Nigeria-Latin American Relations.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.