The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker
Abstract
TMPRSS2‐ERG fusion occurs in about half of prostate cancers and results in over‐expression of the oncogenic ERG protein in the prostate. The mechanism by which ERG contributes to prostate cancer initiation and progression remains largely unknown. Because ERG is a transcriptional activator, we reasoned that the target genes regulated by ERG could contribute to prostate cancer development.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 08, 2016
- Source ID
- 10.1002/pros.23213
Entities
People
- Anna Frolov
- Baijun Dong
- Bin He
- Dean P. Edwards
- John P. Lydon
- Lijuan Xiao
- Michael A. Mancini
- Michael M. Ittmann
- Patricia D Castro
- Qin Feng
- Rainer B. Lanz
- Sung Yun Jung
- Wei Xue
- Zheng Zhang
Organizations
- American Cancer Society
- Baylor College of Medicine
- Dan L. Duncan Cancer Center, Baylor College of Medicine
- Shanghai Jiao Tong University
- United States Department of Defense