Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA‐repair gene mutations in prostate cancer
Abstract
Germline mutations in genes mediating DNA repair are common in men with recurrent and advanced prostate cancer, and their presence may alter prognosis and management. We aimed to define pathological and clinical characteristics associated with germline DNA‐repair gene mutations, to facilitate selection of patients for germline testing.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 25, 2018
- Source ID
- 10.1002/pros.23484
Entities
People
- Emmanuel S. Antonarakis
- John L. Silberstein
- Jun Luo
- Mark C Markowski
- Pedro Isaacsson Velho
- Tamara L Lotan
- William B Isaacs
Organizations
- Johns Hopkins School of Medicine
- Johns Hopkins University
- National Institutes of Health
- United States Department of Defense