A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer

Abstract

Germline mutations in CHEK2 have been associated with prostate cancer (PCa) risk. Our objective is to examine whether germline pathogenic CHEK2 mutations can differentiate risk of lethal from indolent PCa.

Document Details

Document Type
Pub Defense Publication
Publication Date
Mar 09, 2018
Source ID
10.1002/pros.23505

Entities

People

  • Brian T. Helfand
  • Charles B. Brendler
  • H. Ballentine Carter
  • Hongjie Yu
  • Jacqueline Petkewicz
  • Jianfeng Xu
  • Kathleen A. Cooney
  • Kathleen Wiley
  • Kristian Novakovic
  • Michael A McGuire
  • Mufaddal Mamawala
  • Qiang Ding
  • Rong Na
  • S. Lilly Zheng
  • Sameep Shah
  • Tricia Landis
  • William B Isaacs
  • Yishuo Wu
  • Zhuqing Shi

Organizations

  • Fudan University
  • Johns Hopkins University
  • NorthShore University HealthSystem
  • Shanghai Jiao Tong University
  • United States Department of Defense
  • University of Utah

Tags

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.