The identification of a novel antibody for CD133 using human antibody phage display

Abstract

The transmembrane glycoprotein CD133 is believed to be a marker of adult prostate stem cells and cancer stem/initiating cells. Investigating the role of CD133 in the normal biology of the prostate and in cancer is complicated by the lack of a sensitive and accurate antibody for its detection. Here, we describe the characterization of a unique antibody identified using human antibody phage display that can recognize CD133 in both formalin‐fixed tissues and cell lines.

Document Details

Document Type
Pub Defense Publication
Publication Date
May 22, 2018
Source ID
10.1002/pros.23656

Entities

People

  • Aaron M LeBeau
  • Colleen L. Forster
  • Hong Zhou
  • Paari Murugan
  • Paige M. Glumac
  • Shilpa Gupta

Organizations

  • National Cancer Institute
  • United States Department of Defense
  • University of Minnesota
  • University of Minnesota Medical School

Tags

Fields of Study

  • Biology

Readers

  • Immunology
  • Materials Science and Engineering.
  • Oncology

Technology Areas

  • Biotechnology