Characterization of novel cell lines derived from a MYC‐driven murine model of lethal metastatic adenocarcinoma of the prostate
Abstract
Background: Loss or mutation of PTEN alleles at 10q23 in combination with 8q24 amplification (encompassing MYC) are common findings in aggressive, human prostate cancer. Our group recently developed a transgenic murine model of prostate cancer involving prostate‐specific Pten deletion and forced expression of MYC under the control of the Hoxb13 promoter. MYC overexpression cooperated with Pten loss to recapitulate lethal, human prostate cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 30, 2018
- Source ID
- 10.1002/pros.23657
Entities
People
- Alexia King
- Angelo M De Marzo
- Apurv Rege
- Charles J Bieberich
- David Esopi
- Gretchen K. Hubbard
- Jessica Hicks
- Mark C Markowski
- Qizhi Zheng
- Srinivasan Yegnasubramanian
Organizations
- American Society of Clinical Oncology
- Congressionally Directed Medical Research Programs
- Johns Hopkins University
- National Cancer Institute
- Prostate Cancer Foundation