Mathematical modeling of intracrine androgen metabolism in prostate cancer: Methodological aspects
Abstract
Progression of castration‐recurrent/resistant prostate cancer (CRPC) relies in part on dihydrotestosterone derived from intratumoral androgen metabolism. Mathematical modeling provides a valuable tool for studies of androgen metabolism in CRPC. This modeling approach integrates existing knowledge about complex biologic systems and provides a means of interrogating the effects of various interventions. We sought to model a single reaction in the androgen biosynthesis network, namely the oxidation of androsterone (AND) to androstanedione (5α‐dione) by four 3α‐oxidoreductase enzymes, as an initial effort to establish the feasibility of our modeling approach.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 25, 2018
- Source ID
- 10.1002/pros.23665
Entities
People
- David S Watt
- James L Mohler
- Michael V Fiandalo
- Robert R Bies
- Sarah F Cook
- Yue Wu
Organizations
- National Cancer Institute
- Roswell Park Comprehensive Cancer Center
- United States Department of Defense
- University at Buffalo
- University of Kentucky