Consequences of interleukin 1β‐triggered chronic inflammation in the mouse prostate gland: Altered architecture associated with prolonged CD4+ infiltration mimics human proliferative inflammatory atrophy
Abstract
Elevated expression of the proinflammatory cytokine interleukin 1β (IL‐1β) has been observed in expressed prostatic secretions of patients with chronic prostatitis/chronic pelvic pain syndrome, and genetic polymorphisms associated with the IL1B gene are linked to increased risk for aggressive prostate cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 22, 2019
- Source ID
- 10.1002/pros.23784
Entities
People
- Angela K. Alme
- Angelo M De Marzo
- Arya Ashok
- Charles G Drake
- Charles J Bieberich
- Jessica Hicks
- Levent Trabzonlu
- Michael Rubenstein
- Qizhi Zheng
- Rebecca Keener
- Sagar Bajpai
- Srinivasan Yegnasubramanian
- Stephanie Stookey
Organizations
- Columbia University
- Congressionally Directed Medical Research Programs
- Foundation for the National Institutes of Health
- Johns Hopkins School of Medicine
- Prostate Cancer Foundation
- University of Maryland