The ternary complex factor protein ELK1 is an independent prognosticator of disease recurrence in prostate cancer
Abstract
Both hormone‐sensitive and castration‐ and enzalutamide‐resistant prostate cancers (PCa) depend on the ternary complex factor (TCF) protein ELK1 to serve as a tethering protein for the androgen receptor (AR) to activate a critical set of growth genes. The two sites in ELK1 required for AR binding are conserved in other members of the TCF subfamily, ELK3 and ELK4. Here we examine the potential utility of the three proteins as prognosticators of disease recurrence in PCa.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 03, 2019
- Source ID
- 10.1002/pros.23932
Entities
People
- Claire Soave
- Luke Pardy
- Manohar Ratnam
- Rayna Rosati
- Seongho Kim
- Yanfang Huang
Organizations
- United States Department of Defense
- Wayne State University