Cancer‐stromal cell fusion as revealed by fluorescence protein tracking
Abstract
We previously determined that cancer‐stromal interaction was a direct route to tumor cell heterogeneity progression, since cancer‐stromal cell fusion in coculture resulted in the creation of heterogeneous clones of fusion hybrid progeny. In this report, we modified the cancer‐stromal coculture system to establish optimal experimental conditions for investigating cell fusion machinery and the mechanism of heterogeneity progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 17, 2019
- Source ID
- 10.1002/pros.23941
Entities
People
- Haiyen E. Zhau
- Ji Lyu
- Leland W. K. Chung
- Michael Lewis
- Ruoxiang Wang
- Stephen J Pandol
Organizations
- Cedars-Sinai Medical Center
- National Cancer Institute
- United States Department of Defense
- VA Greater Los Angeles Healthcare System