Characterization of tumor‐associated macrophages in prostate cancer transgenic mouse models
Abstract
Tumor‐associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and progression of a tumor. Therefore, genetically engineered mouse models are essential for studying the TME as well as advancing TAM‐targeted therapies. Two common transgenic (TG) models of prostate cancer are Hi‐Myc and transgenic adenocarcinoma of the mouse prostate (TRAMP), but the TME and TAM characteristics of these models have not been well characterized.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 05, 2021
- Source ID
- 10.1002/pros.24139
Entities
People
- Alexandria Brame
- Amber E. de Groot
- Angelo M De Marzo
- Ashley L. Kiemen
- Denis Wirtz
- Kayla V Myers
- Kenneth J. Pienta
- Levent Trabzonlu
- Natalia H. Nagy
- Sarah R Amend
- Timothy E Krueger
- Vicente E. Torres
- W Nathaniel Brennen
- Zhongyuan Zhang
Organizations
- Johns Hopkins School of Medicine
- Loyola University Chicago
- Prostate Cancer Foundation
- United States Department of Defense