Advanced glycation end‐products (AGEs) are lower in prostate tumor tissue and inversely related to proportion of West African ancestry

Abstract

The metabolism of normal prostate relies on glycolysis, with prostate cancer having reduced glycolysis and increased aerobic metabolism. Advanced glycation end products (AGEs) accumulate in tissues as a result of age and glycolytic rate. Differential AGE levels were recently observed in prostate cancer tissues. Herein we sought to quantify AGEs in benign and cancer prostate tissue in a diverse cohort of patients.

Document Details

Document Type
Pub Defense Publication
Publication Date
Dec 02, 2021
Source ID
10.1002/pros.24273

Entities

People

  • Adam B Murphy
  • Andre Kajdacsy‐balla
  • Cindy Voisine
  • Hing Ong
  • Larisa Nonn
  • Marcus Murray
  • Maria Sverdlov
  • Morgan L. Zenner
  • Ryan J. Deaton
  • Sarki A. Abdulkadir
  • Virgilia Macias
  • Yves B. Helou

Organizations

  • National Center for Advancing Translational Sciences
  • Northeastern Illinois University
  • Northwestern University
  • United States Department of Defense
  • United States Department of Veterans Affairs
  • University of Illinois at Chicago

Tags

Readers

  • Immunology and Pathology
  • Molecular and Cellular Biology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.