Bipolar androgen therapy (BAT): A patient's guide
Abstract
Bipolar androgen therapy (BAT) is a new treatment concept for men whose prostate cancer has become resistant to standard hormone‐blocking therapy. Over the past decade, we have performed a series of clinical studies testing BAT in asymptomatic men with castration‐resistant prostate cancer. The key findings from these clinical studies are that BAT (a) can be safely administered to asymptomatic patients with metastatic castrate‐resistant prostate cancer; (b) does not produce symptomatic disease progression; (c) produces sustained prostate‐specific antigen and objective responses in 30%–40% of patients; and (d) can resensitize and prolong response to subsequent antiandrogen therapy. The concept of BAT has generated significant interest from men with prostate cancer, their families, and their physicians. Here we provide a “Patient's Guide” that answers questions about BAT in a form that is accessible to patients, their families, and physicians. Our goal is to provide information to help patients make the most informed decisions they can regarding their prostate cancer treatment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 31, 2022
- Source ID
- 10.1002/pros.24328
Entities
People
- Emmanuel S. Antonarakis
- Mark C Markowski
- Samuel Denmeade
Organizations
- National Institutes of Health
- Prostate Cancer Foundation
- United States Department of Defense
- University of Minnesota