Germline genetics of prostate cancer

Abstract

An important fraction (>/~10%) of men with high‐risk, localized prostate cancer and metastatic prostate cancer carry germline (heritable) pathogenic and likely pathogenic variants (also known as mutations) in DNA repair genes. These can represent known or suspected autosomal dominant cancer predisposition syndromes. Growing evidence suggests that pathogenic variants in key genes involved in homologous recombination and mismatch DNA repair are important in prostate cancer initiation and/or the development of metastases.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 03, 2022
Source ID
10.1002/pros.24340

Entities

People

  • Heather H Cheng
  • Hiba M. Khan

Organizations

  • Fred Hutchinson Cancer Center
  • National Institutes of Health
  • Prostate Cancer Foundation
  • United States Department of Defense
  • University of Washington

Tags

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology