Racial differences in circulating mitochondria‐derived peptides may contribute to prostate cancer health disparities
Abstract
The mitochondrial genome has small open reading frames (sORF) which produce measurable mitochondrial‐derived peptides (MDPs), including humanin, SHLP2, and MOTS‐c. Previously, among men undergoing prostate biopsy, we found higher serum SHLP2 was linked with lower prostate cancer (PC) risk in European American men (EAM), while null associations were found in African American men (AAM). Here, in different patients undergoing prostate biopsy, we tested the link between SHLP2, humanin and MOTS‐c and PC risk by race.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 05, 2022
- Source ID
- 10.1002/pros.24398
Entities
People
- Adela Ramirez‐torres
- Adriana C. Vidal
- Allison L. Reagan
- Brendan Miller
- Emily K Wiggins
- Junxiang Wan
- Lauren E. Howard
- Pinchas Cohen
- Stephen J. Freedland
Organizations
- Department of Surgery
- Duke University
- National Institutes of Health
- United States Department of Defense