Increased cytokine gene expression and cognition risk associated with androgen deprivation therapy

Abstract

Androgen deprivation therapy (ADT) is a standard treatment modality for locally advanced, high‐risk, and metastatic hormone‐sensitive prostate cancer. Long‐term ADT treatment likely develops side‐effects that include changes in cognition or onset of dementia. However, the molecular understanding of this effect remains elusive. We attempt to establish a link between ADT and changes in cognitive function using patient databases and bioinformatics analyses.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jul 12, 2022
Source ID
10.1002/pros.24411

Entities

People

  • Eswar Shankar
  • Lee E. Ponsky
  • Prem Prakash Kushwaha
  • Sanjay Gupta
  • Shiv Verma

Organizations

  • Case Western Reserve University
  • Mental Illness Research, Education and Clinical Centers
  • United States Department of Defense

Tags

Fields of Study

  • Medicine
  • Psychology

Readers

  • Database Systems and Applications
  • Molecular Biology and Genetics
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