Presence of cells in the polyaneuploid cancer cell (PACC) state predicts the risk of recurrence in prostate cancer
Abstract
The nonproliferating polyaneuploid cancer cell (PACC) state is associated with therapeutic resistance in cancer. A subset of cancer cells enters the PACC state by polyploidization and acts as cancer stem cells by undergoing depolyploidization and repopulating the tumor cell population after the therapeutic stress is relieved. Our aim was to systematically assess the presence and importance of this entity in men who underwent radical prostatectomy with curative intent to treat their presumed localized prostate cancer (PCa).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 13, 2022
- Source ID
- 10.1002/pros.24459
Entities
People
- Angelo M De Marzo
- Bruce J Trock
- Kenneth J. Pienta
- Levent Trabzonlu
- Sarah R Amend
Organizations
- Congressionally Directed Medical Research Programs
- Johns Hopkins University
- Loyola University Chicago
- National Cancer Institute
- Prostate Cancer Foundation