Activity of native tick kinins and peptidomimetics on the cognate target G protein‐coupled receptor from the cattle fever tick, Rhipicephalus microplus (Acari: Ixodidae)
Abstract
Kinins are multifunctional neuropeptides that regulate key insect physiological processes such as diuresis, feeding, and ecdysis. However, the physiological roles of kinins in ticks are unclear. Furthermore, ticks have an expanded number of kinin paracopies in the kinin gene. Silencing the kinin receptor (KR) in females of Rhipicephalus microplus reduces reproductive fitness. Thus, it appears the kinin signaling system is important for tick physiology and its disruption may have potential for tick control.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 08, 2020
- Source ID
- 10.1002/ps.5704
Entities
People
- Caixing Xiong
- Janusz Zabrocki
- Krzysztof Kaczmarek
- Patricia V Pietrantonio
- Ronald J. Nachman
Organizations
- National Institute of Food and Agriculture
- United States Department of Defense
- Łódź University of Technology