Empirical likelihood confidence interval for sensitivity to the early disease stage
Abstract
Disease status can naturally be classified into three or more ordinal stages rather than just being binary stages. Many works have been done for the estimation and inference procedure regarding three ordinal disease stages, which are non‐disease, early disease, and full disease stages. The early disease stage can be very important for therapeutic intervention and prevention potentiality. As a diagnostic measure, sensitivity to the early disease stage is often used. In this article, we propose confidence intervals for the sensitivity to early disease stage based on given target specificity for non‐disease stage and target sensitivity to full disease stage using both empirical likelihood (EL) and adjusted EL procedures. We compare the performance of the proposed EL confidence intervals with other procedures in our simulation study. The proposed procedures are further applied to Alzheimer's Disease Neuroimaging Initiative data set.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 27, 2021
- Source ID
- 10.1002/pst.2186
Entities
People
- For The Alzheimer’s Disease Neuroimaging Initiative*
- Husneara Rahman
- Yichuan Zhao
Organizations
- Georgia State University
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- Simons Foundation
- United States Department of Defense