Novel left ventricular mechanical index in pulmonary arterial hypertension
Abstract
Ventricular interdependence plays an important role in pulmonary arterial hypertension (PAH). It can decrease left ventricular (LV) longitudinal strain (LVLS) and lead to a leftward displacement (“transverse shortening”) of the interventricular septum (sTS). For this study, we hypothesized the ratio of LVLS/sTS would be a sensitive marker of systolic ventricular interactions in PAH. In a cross‐sectional cohort of patients with PAH (n = 57) and matched controls (n = 57), we quantified LVLS and septal TS in the amplitude and time domain. We then characterized LV phenotypes using upset plots, ventricular interactions using network analysis, and longitudinal analysis in a representative cohort of 45 patients. We also measured LV metrics in mice subjected to pulmonary arterial banding (PAB) using a 7 T magnetic resonance imaging at baseline, Week 1, and Week 7 post‐PAB (N = 9). Patients with PAH had significantly reduced absolute LVLS (15.4 ± 3.4 vs. 20.1 ± 2.3%, p p p r = 0.73, p < 0.0001) as well as survival. Mice subjected to PAB showed significant RV systolic dysfunction and decreased LVLS/sTS compared to sham animals. We conclude that in PAH, LVLV/sTS is a simple ratio that can reflect ventricular systolic interactions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2023
- Source ID
- 10.1002/pul2.12216
Entities
People
- Edda Spiekerkoetter
- Everton José Santana
- Francois Haddad
- František Sabovčik
- Kenzo Ichimura
- Lindsey Chun
- Michael Salerno
- Nadia L. C. Francisco
- Nicholas Cauwenberghs
- Roham T. Zamanian
- Tatiana Kuznetsova
- Vitaly O Kheyfets
Organizations
- Actelion
- American Heart Association
- National Heart, Lung, and Blood Institute
- National Institutes of Health
- Stanford University
- United States Department of Defense
- University of Colorado