Validation of a quantitative liquid chromatography/hybrid quadrupole‐linear ion trap MS/MS method for carfentanil and caffeine in a live human epidermis model
Abstract
Carfentanil, an opioid 10K times more potent than morphine, has no licit clinical use. A powerful CNS depressant, it has been identified increasingly as the cause of overdose death in the United States. Because it is highly lipophilic, the law enforcement and medical communities have been concerned that responding personnel could be percutaneously exposed and that exposure could be enhanced with the use of alcohol‐containing hand sanitizers. An LC‐MS/MS method was developed to evaluate solvent effects on percutaneous absorption of carfentanil in a live human epidermal model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 07, 2022
- Source ID
- 10.1002/rcm.9420
Entities
People
- David Kilgour
- Jonathan M. Oyler
- Kathleen J. Maistros
Organizations
- Defense Threat Reduction Agency
- Nottingham Trent University
- United States Army Medical Research Institute of Chemical Defense