The mammalian blastema: regeneration at our fingertips
Abstract
In the mouse, digit tip regeneration progresses through a series of discrete stages that include inflammation, histolysis, epidermal closure, blastema formation, and redifferentiation. Recent studies reveal how each regenerative stage influences subsequent stages to establish a blastema that directs the successful regeneration of a complex mammalian structure. The focus of this review is on early events of healing and how an amputation wound transitions into a functional blastema. The stepwise formation of a mammalian blastema is proposed to provide a model for how specific targeted treatments can enhance regenerative performance in humans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2015
- Source ID
- 10.1002/reg2.36
Entities
People
- Jennifer Simkin
- Ken Muneoka
- Lindsay A Dawson
- Ling Yu
- Mimi C. Sammarco
- Paula P. Schanes
Organizations
- Defense Advanced Research Projects Agency
- Tulane University of Louisiana