High Relaxivity Gadolinium‐Polydopamine Nanoparticles
Abstract
This study reports the preparation of a series of gadolinium‐polydopamine nanoparticles (GdPD‐NPs) with tunable metal loadings. GdPD‐NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7‐tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM−1 s−1 at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD‐NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T1‐weighted, high relaxivity MRI contrast agents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 10, 2017
- Source ID
- 10.1002/smll.201701830
Entities
People
- Fabio Carniato
- Jeffrey D Rinehart
- Mauro Botta
- Nanzhi Zang
- Nathan C. Gianneschi
- Sha He
- Yijun Xie
- Yiwen Li
- Yuran Huang
- Zhao Wang
Organizations
- Air Force Office of Scientific Research
- Fondazione Compagnia di San Paolo
- Northwestern University
- Sichuan University
- University of California, San Diego
- University of Eastern Piedmont