Design Rules for Template‐Confined DNA‐Mediated Nanoparticle Assembly
Abstract
Template‐based strategies are becoming increasingly important for controlling the position of nanoparticle‐based (NP‐based) structures on surfaces for a wide variety of encoding and device fabrication strategies. Thus, there is an increasing need to understand the behavior of NPs in confined spaces. Herein, a systematic investigation of the diffusion and adsorption properties of DNA‐modified NPs is presented in lithographically defined, high‐aspect‐ratio pores using a template‐confined, DNA‐mediated assembly. Leveraging the sequence‐specific binding affinity of DNA, it is discovered that although NP adsorption in deep polymer pores follows a traditional Langmuir adsorption model when under thermodynamic control, such NPs kinetically follow Fick's classical law of diffusion. Importantly, these observations allow one to establish design rules for template‐confined, DNA‐mediated NP assembly on substrates based on pore dimensions, NP size and shape, NP concentration, temperature, and time. As a proof‐of‐concept example, these design rules are used to engineer a vertical, four‐layer assembly consisting of individual octahedral NPs stacked on top of one another, with in‐plane positioning defined by pores generated by e‐beam lithography.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 24, 2018
- Source ID
- 10.1002/smll.201802742
Entities
People
- Chad Mirkin
- Jarad A Mason
- Qing‐yuan Lin
- Vinayak P. Dravid
- Wenjie Zhou
Organizations
- Air Force Office of Scientific Research
- Ecumenical Project for International Cooperation
- National Science Foundation
- Northwestern University