Self‐Assembly of Microparticles by Supramolecular Homopolymerization of One Component DNA Molecule
Abstract
DNA is a superb molecule for self‐assembly of nanostructures. Often many DNA strands are required for the assembly of one DNA nanostructure. For lowering the cost of synthesizing DNA strands and facilitating the assembly process, it is highly desirable to use a minimal number of unique strands for potential technological applications. Herein, a strategy is reported to assemble a series of DNA microparticles (DNAµPs) from one component DNA strand. As a demonstration of the application of the resulting DNAµPs, the design and assembled DNAµPs are modified to carry additional single‐stranded tails on their surfaces. The modified DNAµPs can either capture other nucleic acids or display CpG motifs to stimulate immune responses.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 08, 2019
- Source ID
- 10.1002/smll.201805552
Entities
People
- Chengde Mao
- Chengzhi Huang
- Hua Zuo
- Huawei He
- Jie Zeng
- Qiushuang Zhu
- Wenhao Fu
- Zhenping Qi
Organizations
- Office of Naval Research
- Purdue University
- Science and Technology Department of Sichuan Province
- Southwest University