Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo
Abstract
Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical‐stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can contribute to the hepatotoxicity of nanotherapeutics beyond the intrinsic hepatotoxicity of nanoparticles (NPs) are poorly understood. Because of this knowledge gap, clinical translation efforts have avoided hepatotoxic molecules. By examining the hepatotoxicity of nanoformulations of known hepatotoxic compounds, it is demonstrated that nanotherapeutics are associated with lower hepatotoxicity than their small‐molecule counterparts. It is also found that the reduced hepatotoxicity is related to the uptake of nanotherapeutics by macrophages in the liver. These findings can facilitate further development and clinical translation of nanotherapeutics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 23, 2020
- Source ID
- 10.1002/smll.201906360
Entities
People
- Andrew Wang
- Bo Sun
- Dong Fu
- Feifei Yang
- Hossein Sendi
- Kim L. R. Brouwer
- Kyle Wagner
- Liantao Li
- Xi Tian
- Yu Mi
- Yusra Medik
Organizations
- Chinese Academy of Meteorological Sciences
- National Cancer Institute
- National Institutes of Health
- Peking Union Medical College
- United States Department of Defense
- University of North Carolina at Chapel Hill
- Xuzhou Medical University