A Microfluidic Ion Sensor Array
Abstract
A balanced concentration of ions is essential for biological processes to occur. For example, [H+] gradients power adenosine triphosphate synthesis, dynamic changes in [K+] and [Na+] create action potentials in neuronal communication, and [Cl−] contributes to maintaining appropriate cell membrane voltage. Sensing ionic concentration is thus important for monitoring and regulating many biological processes. This work demonstrates an ion‐selective microelectrode array that simultaneously and independently senses [K+], [Na+], and [Cl−] in electrolyte solutions. To obtain ion specificity, the required ion‐selective membranes are patterned using microfluidics. As a proof of concept, the change in ionic concentration is monitored during cell proliferation in a cell culture medium. This microelectrode array can easily be integrated in lab‐on‐a‐chip approaches to physiology and biological research and applications.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 22, 2020
- Source ID
- 10.1002/smll.201906436
Entities
People
- Brian Nguyen
- Chunxiao Wu
- Harika Dechiraju
- John Selberg
- Manping Jia
- Marco Rolandi
- Mircea Teodorescu
- Pattawong Pansodtee
Organizations
- Army Research Office
- Defense Advanced Research Projects Agency
- University of California