Drawn‐on‐Skin Sensors from Fully Biocompatible Inks toward High‐Quality Electrophysiology
Abstract
The need to develop wearable devices for personal health monitoring, diagnostics, and therapy has inspired the production of innovative on‐demand, customizable technologies. Several of these technologies enable printing of raw electronic materials directly onto biological organs and tissues. However, few of them have been thoroughly investigated for biocompatibility of the raw materials on the cellular, tissue, and organ levels or with different cell types. In addition, highly accurate multiday in vivo monitoring using such on‐demand, in situ fabricated devices has yet to be done. Presented herein is the first fully biocompatible, on‐skin fabricated electronics for multiple cell types and tissues that can capture electrophysiological signals with high fidelity. While also demonstrating improved mechanical and electrical properties, the drawn‐on‐skin ink retains its properties under various writing conditions, which minimizes the variation in electrical performance. Furthermore, the drawn‐on‐skin ink shows excellent biocompatibility with cardiomyocytes, neurons, mice skin tissue, and human skin. The high signal‐to‐noise ratios of the electrophysiological signals recorded with the DoS sensor over multiple days demonstrate its potential for personalized, long‐term, and accurate electrophysiological health monitoring.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 19, 2022
- Source ID
- 10.1002/smll.202107099
Entities
People
- Abdelmotagaly Elgalad
- Alamgir Karim
- Aman Agarwal
- Arturo Haces‐garcia
- Cunjiang Yu
- Faheem Ershad
- Grace Liu
- Igor R. Efimov
- Jimmy Lee
- Lei Gonzalez
- Lourdes Chacon‐Alberty
- Luis Contreras
- Marco A. Morales‐Garza
- Min Zhao
- Roslyn Rivkah Isseroff
- Seonmin Jang
- Shubham Patel
- Weihang Zhu
- Xiaoyang Wu
- Yifan Wang
- Yu Shrike Zhang
- Zhoulyu Rao
Organizations
- Bellaire High School
- George Washington University
- Harvard Medical School
- National Science Foundation
- Office of Naval Research
- Texas Heart Institute
- University of California, Davis
- University of Chicago
- University of Houston