Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells
Abstract
Particles that preferentially partition to a specific cellular subunit, such as the nucleus, mitochondria, or the cytoskeleton, are of relevance to a number of applications, including drug delivery, genetic manipulation, or self‐assembly. Here, hierarchical assemblies of fully synthetic particles that selectively localize to the plasma membrane of mammalian cells are presented. A multimodal approach is used to create assemblies of polymer‐based carrier particles with amphiphilic gold nanoparticles immobilized on one hemisphere. These assemblies persist in the plasma membrane of cells for several days and undergo rearrangements and clustering, typically considered to be hallmarks of membrane‐bound receptors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 28, 2019
- Source ID
- 10.1002/smtd.201800408
Entities
People
- Asish C. Misra
- Francesco Stellacci
- Giulia Rusciano
- Joerg Lahann
- Randy P. Carney
- Tae‐hong Park
Organizations
- Defense Threat Reduction Agency
- Karlsruhe Institute of Technology
- Seventh Framework Programme
- Swiss Federal Institute of Technology in Lausanne
- University of Michigan
- University of Naples Federico II