Concise Review: Prostate Cancer Stem Cells: Current Understanding
Abstract
Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that possess many phenotypic and functional properties of normal stem cells. Since the initial reports on PCSCs in 2005, there has been much effort to elucidate their biological properties, including unique metabolic characteristics. In this Review, we discuss the current methods for PCSC enrichment and analysis, the hallmarks of PCSC metabolism, and the role of PCSCs in tumor progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 27, 2018
- Source ID
- 10.1002/stem.2859
Entities
People
- Anna Dubrovska
- Dean Tang
- Ira-ida Skvortsova
- Sergej Skvortsov
Organizations
- Austrian National Bank
- Austrian Science Fund
- Federal Ministry of Research, Technology and Space
- German Aerospace Center
- German Research Foundation
- Medical University of Innsbruck
- Ministry of Science and Technology of the People's Republic of China
- National Cancer Institute
- National Institutes of Health
- Roswell Park Comprehensive Cancer Center
- Technische Universität Dresden
- Tongji University
- United States Department of Defense