Reengineering a falloposcope imaging system for clinical use
Abstract
Highâgrade serous carcinoma of the ovary is believed to originate in the fallopian tubes (FTs). A submillimeter diameter endoscope with advanced imaging capabilities may take advantage of the natural pathway of the female reproductive tract to image the FTs in a minimally invasive procedure for early detection of cancer. Our lab previously built a prototype benchtop FT endoscope with pseudowhite light imaging, multispectral fluorescence imaging and optical coherence tomography. This endoscope was approximately 0.9 mm in diameter, flexible and steerable in one direction. Several modifications have been made to create a falloposcope imaging system which is ready for clinical use. This new design includes a multilumen extrusion, a revised handle design, simplified lens design and redesigned subsystems resulting in improved mechanical characteristics, biocompatibility and portability while maintaining image quality. Additionally, these clinical endoscopes are single use, considerably less expensive and faster to build as compared to the prototype.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 26, 2020
- Source ID
- 10.1002/tbio.202000011
Entities
People
- Dominique Galvez
- Gabriella Romano
- Jennifer Barton
- John Heusinkveld
- Kelli C. Kiekens
- Kenneth Hatch
- Ricky Cordova
- William Drake
- Zaynah Kmeid
Organizations
- United States Department of Defense
- University of Arizona