Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease
Abstract
Possession of the apolipoprotein E (APOE) ε4 allele advances amyloid β (Aβ) deposition and symptomatic onset of Alzheimer's disease (AD), whereas its effect on the rate of cognitive decline remained controversial. We examined the effects of APOE ε4 allele on cognition in biomarker‐confirmed late mild cognitive impairment (LMCI) and mild AD subjects in the Japanese Alzheimer's Disease Neuroimaging Initiative (J‐ADNI) and North American ADNI (NA‐ADNI).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2020
- Source ID
- 10.1002/trc2.12007
Entities
People
- Akihiro Hirakawa
- Alzheimer's Disease Neuroimaging Initiative, Japanese Alzheimer's Disease Neuroimaging Initiative
- Atsushi Iwata
- Chung‐kai Sun
- Kazushi Suzuki
- Kenji Ishii
- Michael Donohue
- Ryoko Ihara
- Takeshi Ikeuchi
- Takeshi Iwatsubo
Organizations
- Alzheimer's Disease Neuroimaging Initiative
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- Niigata University
- Tokyo Metropolitan Institute of Gerontology
- United States Department of Defense
- University of Southern California
- University of Tokyo