Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy
Abstract
Photodynamic therapy (PDT) has emerged as an attractive option for cancer treatment. However, conventional PDT is activated by light that has poor tissue penetration depths, limiting its applicability in the clinic. Recently the idea of using X‐ray sources to activate PDT and overcome the shallow penetration issue has garnered significant interest. This can be achieved by external beam irradiation and using a nanoparticle scintillator as transducer. Alternatively, research on exploiting Cherenkov radiation from radioisotopes to activate PDT has also begun to flourish. In either approach, the most auspicious success is achieved using nanoparticles as either a scintillator or a photosensitizer to mediate energy transfer and radical production. Both X‐ray induced PDT (X‐PDT) and Cherenkov radiation PDT (CR‐PDT) contain a significant radiation therapy (RT) component and are essentially PDT and RT combination. Unlike the conventional combination, however, in X‐PDT and CR‐PDT, one energy source simultaneously activates both processes, making the combination always in synchronism and the synergy potential maximized. While still in early stage of development, X‐PDT and CR‐PDT address important issues in the clinic and hold great potential in translation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 31, 2018
- Source ID
- 10.1002/wnan.1541
Entities
People
- Benjamin Cline
- Ian Delahunty
- Jin Xie
Organizations
- Congressionally Directed Medical Research Programs
- National Institutes of Health
- National Science Foundation
- University of Georgia