Nanomedicine and nanobiotechnology applications of magnetoelectric nanoparticles
Abstract
Unlike any other nanoparticles known to date, magnetoelectric nanoparticles (MENPs) can generate relatively strong electric fields locally via the application of magnetic fields and, vice versa, have their magnetization change in response to an electric field from the microenvironment. Hence, MENPs can serve as a wireless two‐way interface between man‐made devices and physiological systems at the molecular level. With the recent development of room‐temperature biocompatible MENPs, a number of novel potential medical applications have emerged. These applications include wireless brain stimulation and mapping/recording of neural activity in real‐time, targeted delivery across the blood–brain barrier (BBB), tissue regeneration, high‐specificity cancer cures, molecular‐level rapid diagnostics, and others. Several independent in vivo studies, using mice and nonhuman primates models, demonstrated the capability to deliver MENPs in the brain across the BBB via intravenous injection or, alternatively, bypassing the BBB via intranasal inhalation of the nanoparticles. Wireless deep brain stimulation with MENPs was demonstrated both in vitro and in vivo in different rodents models by several independent groups. High‐specificity cancer treatment methods as well as tissue regeneration approaches with MENPs were proposed and demonstrated in in vitro models. A number of in vitro and in vivo studies were dedicated to understand the underlying mechanisms of MENPs‐based high‐specificity targeted drug delivery via application of d.c. and a.c. magnetic fields.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 03, 2022
- Source ID
- 10.1002/wnan.1849
Entities
People
- Aidan Scott‐vandeusen
- Burak Yıldırım
- Elric Zhang
- Isadora Takako Smith
- Manuel Alberteris Campos
- Mostafa Abdel‐mottaleb
- Ping Liang
- Sakhrat Khizroev
- Victoria Louise Andre
- Yagmur Akin Yildirim
- Zeinab Ramezani
Organizations
- Defense Advanced Research Projects Agency
- National Science Foundation
- University of Miami