Alternative RNA splicing and cancer
Abstract
Alternative splicing of pre‐messenger RNA (mRNA) is a fundamental mechanism by which a gene can give rise to multiple distinct mRNA transcripts, yielding protein isoforms with different, even opposing, functions. With the recognition that alternative splicing occurs in nearly all human genes, its relationship with cancer‐associated pathways has emerged as a rapidly growing field. In this review, we summarize recent findings that have implicated the critical role of alternative splicing in cancer and discuss current understandings of the mechanisms underlying dysregulated alternative splicing in cancer cells. WIREs RNA 2013, 4:547–566. doi: 10.1002/wrna.1178
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 13, 2013
- Source ID
- 10.1002/wrna.1178
Entities
People
- Chonghui Cheng
- Sali Liu
Organizations
- American Association for Cancer Research
- American Cancer Society
- Northwestern University
- United States Department of Defense