Regulation of mRNA turnover in cystic fibrosis lung disease
Abstract
Cystic fibrosis (CF) is an autosomal recessive disease due to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, F508del‐CFTR being the most frequent mutation. The CF lung is characterized by a hyperinflammatory phenotype and is regulated by multiple factors that coordinate its pathophysiology. In CF the expression of CFTR as well as proinflammatory genes are regulated at the level of messenger RNA (mRNA) stability, which subsequently affect translation. These mechanisms are mediated by inflammatory RNA‐binding proteins as well as small endogenous noncoding microRNAs, in coordination with cellular signaling pathways. These regulatory factors exhibit altered expression and function in vivo in the CF lung, and play a key role in the pathophysiology of CF lung disease. In this review, we have described the role of mRNA stability and associated regulatory mechanisms in CF lung disease. WIREs RNA 2017, 8:e1408. doi: 10.1002/wrna.1408
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 13, 2016
- Source ID
- 10.1002/wrna.1408
Entities
People
- Harvey B. Pollard
- Parameet Kumar
- Roopa Biswas
Organizations
- Cystic Fibrosis Foundation
- Uniformed Services University of the Health Sciences