Recent advancement of light‐based single‐molecule approaches for studying biomolecules
Abstract
Recent advances in single‐molecule techniques have led to new discoveries in analytical chemistry, biophysics, and medicine. Understanding the structure and behavior of single biomolecules provides a wealth of information compared to studying large ensembles. However, developing single‐molecule techniques is challenging and requires advances in optics, engineering, biology, and chemistry. In this paper, we will review the state of the art in single‐molecule applications with a focus over the last few years of development. The advancements covered will mainly include light‐based in vitro methods, and we will discuss the fundamentals of each with a focus on the platforms themselves. We will also summarize their limitations and current and future applications to the wider biological and chemical fields.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 06, 2019
- Source ID
- 10.1002/wsbm.1445
Entities
People
- Benjamin Croop
- Chenyi Zhang
- Kyu Young Han
- Ryan M. Gelfand
- Youngbin Lim
Organizations
- Defense Advanced Research Projects Agency
- Division of Chemical, Bioengineering, Environmental, and Transport Systems
- Stanford University
- University of Central Florida