TLR7 activation in epilepsy of tuberous sclerosis complex
Abstract
Neuroinflammation and toll-like receptors (TLR) of the innate immune system have been implicated in epilepsy. We previously reported high levels of microRNAs miR-142-3p and miR-223-3p in epileptogenic brain tissue resected for the treatment of intractable epilepsy in children with tuberous sclerosis complex (TSC). As miR-142-3p has recently been reported to be a ligand and activator of TLR7, a detector of exogenous and endogenous single-stranded RNA, we evaluated TLR7 expression and downstream IL23A activation in surgically resected TSC brain tissue.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 11, 2019
- Source ID
- 10.1007/s00011-019-01283-3
Entities
People
- Alan A Dombkowski
- Daniela Cukovic
- Diane C. Chugani
- Harry T. Chugani
- Joseph A. Caruso
- Mckenzie Jones
- Shruti Bagla
Organizations
- Children's Hospital of Michigan
- National Institute of Neurological Disorders and Stroke
- United States Army