Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain
Abstract
Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder & widespread pain can be explained by shared underlying genetic variants; and (ii) higher CRP levels causally contribute to these conditions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 17, 2023
- Source ID
- 10.1007/s00586-023-07711-7
Entities
People
- Adrián I. Campos
- David M Klyne
- Gabriel Cuellar-partida
- Michele Sterling
- Miguel E. Rentería
- Mischa Lundberg
- Pik-fang Kho
- Sanam Mustafa
- Scott F. Farrell
- Trung Thanh Ngo
Organizations
- Queensland University of Technology
- United States Department of Defense
- University of Queensland