Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia
Abstract
Longitudinal mouse models of brain arteriovenous malformations (AVMs) are crucial for developing novel therapeutics and pathobiological mechanism discovery underlying brain AVM progression and rupture. The sustainability of existing mouse models is limited by ubiquitous Cre activation, which is associated with lethal hemorrhages resulting from AVM formation in visceral organs. To overcome this condition, we developed a novel experimental mouse model of hereditary hemorrhagic telangiectasia (HHT) with CreER-mediated specific, localized induction of brain AVMs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 23, 2023
- Source ID
- 10.1007/s10456-023-09881-w
Entities
People
- Chul Han
- Ethan A. Winkler
- Joshua S. Catapano
- Lea Scherschinski
- Michael T. Lawton
- Peter Vajkoczy
- Suk Paul Oh
- Tyler D. Schriber
- Yong Hwan Kim
Organizations
- Leducq Foundation
- United States Department of Defense