Investigating the role of endogenous estrogens, hormone replacement therapy, and blockade of estrogen receptor-α activity on breast metabolic signaling
Abstract
Menopause is associated with an increased risk of estrogen receptor-positive (ER +) breast cancer. To characterize the metabolic shifts associated with reduced estrogen bioavailability on breast tissue, metabolomics was performed from ovary-intact and ovariectomized (OVX) female non-human primates (NHP). The effects of exogenous estrogen administration or estrogen receptor blockade (tamoxifen treatment) on menopause-induced metabolic changes were also investigated.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 26, 2021
- Source ID
- 10.1007/s10549-021-06354-w
Entities
People
- Alana A. Arnone
- David R. Soto-pantoja
- J. Mark Cline
- Katherine Cook
Organizations
- American Cancer Society
- American Society for Radiation Oncology
- Congressionally Directed Medical Research Programs
- Susan G. Komen for the Cure
- The Breast Cancer Research Foundation