Highly accurate response prediction in high-risk early breast cancer patients using a biophysical simulation platform
Abstract
Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in early breast cancer (EBC) is largely dependent on breast cancer subtype, but no clinical-grade model exists to predict response and guide selection of treatment. A biophysical simulation of response to NAC has the potential to address this unmet need.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 05, 2022
- Source ID
- 10.1007/s10549-022-06722-0
Entities
People
- Alexander T Pearson
- Frederick M. Howard
- Gong He
- Hiroyuki Abe
- J. R. Pfeiffer
- John A. Cole
- Joseph R. Peterson
- Rita Nanda
- Tyler Earnest
Organizations
- National Cancer Institute
- National Institute of Dental and Craniofacial Research
- United States Department of Defense